IVF technology with 24/7 embryo monitoring
New IVF technology with 24/7 embryo monitoring
Time-lapse monitoring of embryos and their development as the latest breakthrough
Time-lapse technology basically involves as a series of 5000 or more snapshot images,
which are then fast forwarded to provide a video-sequence of the embryos developing.
You may have seen this on natural history programmes where it is used to show a
plant growing of flower blossoming.
The systems of microscopic monitoring are the newest development in the field of
Assisted Reproduction and are expected to provide important information and answers
for the embryo development and the possibility of embryo implantation in IVF programmes.
And this is because they monitor and record the development of each embryo 24 hours
Special microscopic lenses are incorporated in the incubators. The embryos are placed
in appropriate places in the incubators which are connected with these lenses and
it is not necessary to move them outside of the incubator for monitoring as the
observation of their development is done with external monitors.
It is like there is a microscope inside the incubator watching night and day the
development of each embryo separately.
Their use does not have any negative influence on the development of the embryos
since the embryos are not affected by their presence. On the contrary, there are
many important advantages like;
- The embryos are not exposed to external lab conditions.
Therefore, there is constant culture and incubation achieving the maximum of quality
for the developing embryos.
- Even more essential is the fact that there is constant
and continuous record that allows us to know important details of the cell development
like for example;
- the exact time between cell division (that is to
say how many hours after the fertilization each embryo was at 2 cells, 3 cells,
- how much time was needed to complete each cell
- if each cell was divided properly, as well as other
very important details that complete the puzzle of each embryo.
It is worth mentioning that these details were impossible to record with the traditional
ways of monitoring of the embryos.
What is it?
- Time-lapse embryo monitoring basically comprises
of equipment which allow embryologists to record the development of the embryos
inside at timed intervals.
- By watching when and how the embryos divide it
is possible to tell whether development is taking place normally.
- Without the embryo monitoring equipment embryologists
are still able to view and record the embryo’s development. However, these activities
will be undertaken at longer intervals, and information relating to exactly when
the embryo divided will be missing.
- Also, it is necessary to remove the embryos from
the incubator in order to inspect them. This in turn exposes them to a change in
temperature and humidity which is not ideal.
Why do I need it?
Embryos containing the incorrect amount of chromosomes in each of their cells (known
as aneuploid) may divide abnormally even though they look normal to the naked eye.
Embryologists will grade embryos on the number of cells, their shape, level of fragmentation,
thickness of the outer shell etc. Without embryo monitoring equipment embryologists
may assess an aneuploid embryo to be normal and decide that it is suitable for transfer.
But, of course, it may not be normal. If it is abnormal, it may not implant or may
lead to a miscarriage. With embryo monitoring, an embryologist has lots of information
on how the embryo divides, what it looks like whilst dividing etc. This information
can be used to assess whether a normal looking embryo is indeed 'normal'. Time-lapse
embryo monitoring can also sometimes determine early on which embryos are most likely
to make it to the blastocyst stage. This may mean that we can transfer embryos earlier
in the knowledge that the best ones have been chosen.
Embryos grow slowly and the technology is perfect to observe them in a laboratory
environment over two to five days. Selecting the right embryos.
Single embryo transfer (SET) is the predominant procedure as in many other countries,
which makes techniques for selecting the most viable embryo even more important.
Primo Vision gives detailed information on the development of embryos over time
and, together with the Arpit Test Tube Baby centre’s experience, provides increased
support in selecting the embryo that is most likely to implant and result in pregnancy.
Embryo evaluation with less stress – embryo safety first
Using Primo Vision Time-Lapse Embryo Monitoring System inside your incubator provides
maximum safety in your culture environment. The system allows you to observe all
embryos without the disturbing incubation conditions or altering your daily routine.
The Primo environment is free of any kind of electromagnetic field effect, the embryos
are not moved and outstanding quality images are captured with minimal light exposure
by Hoffmann modulation contrast.
The Time-Lapse technology enables to objectively assess embryo development in order
to transfer or freeze the best quality embryo and to increase your chances of becoming